Micky van de Ven Double Halts The Toffees' Run at New Home Ground
The Dutch defender became the initial backline player to score twice in a Premier League match for Spurs since Jan Vertonghen in March 2013.
Key points
Micky Van de Ven heads home two times in first half
Everton's defender has goal disallowed after VAR review
Senegalese midfielder scores third in 89th minute
This loss is the Merseyside club's initial at their new ground
The Tottenham defender scored twice as Tottenham prolonged their unbeaten run in away games in the top division and delivered the Toffees their first defeat at Hill Dickinson Stadium.
The Toffees were unbeaten in their last five matches at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after 133 years at the end of last season.
But Tottenham's leader the Dutchman pounced on two occasions from corners in the opening 45 minutes to place their strong form at jeopardy, and they were unable to turn it around before the midfielder - assisted by ex-Everton forward Richarlison - headed home a final goal to seal the victory.
Jake O'Brien thought he had levelled the tally five minutes after the defender's first goal, glancing a powerful header past the Spurs keeper from an Everton corner.
The Portuguese striker, meanwhile, missed a number of opportunities, while Vicario made a succession of excellent stops to ensure the London club went five away games unbeaten in the Premier League.
But the VAR stepped in, instructing Craig Pawson to check the goal on the pitchside monitor and the official ruled that the winger and Iliman Ndiaye were in offside positions and had interfered with the Tottenham goalkeeper.
This victory elevates Thomas Frank's side into third place in the Premier League, a handful of points off local foes and leaders Arsenal.
The Merseyside club stay 14th and are half a dozen points ahead of the relegation zone.
Spurs breakdown: Van de Ven excels in duties at each end of pitch
Following a drab weekday performance in the European competition against Monaco, where they mustered a mere attempts on target, the manager opted for the French striker in attack instead of ex-Everton forward Richarlison.
The new arrival was unable to influence the game before being replaced for the substitute after an hour on the pitch, but it turns out he wasn't needed in the end.
Defender the Dutchman transformed into an offensive threat to be reckoned with.
Spurs' opening strike came from a well-worked corner routine, with Rodrigo Bentancur directing the ball back across the face of goal for an unmarked Van de Ven to head home.
And Ven de Ven - filling in as captain in the Argentine's absence - added his next goal in added time as he rose above Jordan Pickford to nod in.
Van de Ven was just as impressive in defence, combining well with Kevin Danso as the duo handled superbly with the numerous deliveries thrown their way by Everton.
Everton analysis: Everton lacking striker's instinct
The club's recent stadium had been a fortress, but it appears the freshness may have faded somewhat and fans flocked to the gates after the midfielder's third for Tottenham.
The break in Everton's winning streak at home will not be a major worry for David Moyes, but their attacking woes will be.
The forward and Thierno Barry - the Everton's two recognised strikers - had scored only a single goal combined before Sunday's outing.
And they were failed to add to that poor tally on a damp and dreary evening on Merseyside.
The striker's performance was summed up when he chose to bicycle-kick a clear chance from close range, despite having space and opportunity to readjust for a more conventional attempt that would have tested Vicario.
Barry, too, failed to influence the game after coming on for Beto in the second half.
It wasn't for a lack of opportunity. The majority of the home side's offensive moves came through the winger and the forward, who tirelessly delivered threatening balls into the Spurs penalty area.
Upcoming fixtures for both teams?
Everton: The team head to Sunderland in the Premier League on early November at 20:00 GMT.
Spurs: Spurs travel to Newcastle's ground on Wednesday, 29 October for their next round League Cup match against the Magpies.